Abu Kamara reportedly crashed into an articulated truck and died on the spot at the Datoyili police barrier about 10:39 pm on Friday night.
He was returning to Tamale after a project inspection tour when the incident occurred.
Mr Kamara died alongside an aide, Majeed Kotochi and one other passenger.
In a short statement, the leadership of the party in the Savannah Region said, “With a heavy heart, the Savannah Regional NPP and the party at large announce the unfortunate demise of our Parliamentary Candidate for the Yapei Kusawgu Constituency, Abu Kamara. He died with an aide, Majeed Kotochi (Young Chief) and another occupant in an unfortunate accident at the Datoyili police barrier. May their Souls Rest In Peace. Amen.”